Peptide Database

Peptide NamePancreatic polypeptide

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide Y family

Standard StatusStandard

Sequence Length36 amino acids

Chemical FormulaC186H284N50O57S2

DescriptionStandard

        APPEPVYPGDDATPEQMAEYVADLRRYINMLTRPRY
    

Molecular Weight4196.68 Da

Isoelectric Point (pI)4.59

Net Charge (pH 7.0)-2.20

Net Charge (pH 7.4) -2.40

Charge Density (pH 7.0) -0.0610

GRAVY Index-0.86

Hydrophobic Moment 0.84

Boman Index-0.14

Instability Index68.86

Aliphatic Index 59.72

Aromaticity 0.1111

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1708.04

LogP -14.16

H-bond Donors 57.0

H-bond Acceptors 57.0

Rotatable Bonds 125.0

Heavy Atoms 295.0

Ring Count 10.0

Amide Bonds 37.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0116819 VERIFIED: NO

Provenance & Taxonomy

OrganismOryctolagus cuniculus [Animal]

Tax ID9986

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone

RECORD: Rec_0189699 VERIFIED: YES

Provenance & Taxonomy

OrganismOryctolagus cuniculus [Animal]

FamilyPancreatic hormone

Tax ID9986

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone Endocrine

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0211211 VERIFIED: YES

Provenance & Taxonomy

OrganismOryctolagus cuniculus [Animal]

FamilyNPY

Tax ID9986

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

NPY-family Neuropeptide Neuromodulator

RECORD: Rec_0341712 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/