Peptide Database

Peptide NamePeptide 3

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HCMV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC32H55N9O10

DescriptionStandard

        GGVLVQPG
    

Molecular Weight725.83 Da

Isoelectric Point (pI)5.53

Net Charge (pH 7.0)-0.24

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0300

GRAVY Index0.74

Hydrophobic Moment 0.25

Boman Index0.49

Instability Index48.25

Aliphatic Index 121.25

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 301.32

LogP -3.18

H-bond Donors 9.0

H-bond Acceptors 10.0

Rotatable Bonds 21.0

Heavy Atoms 51.0

Ring Count 1.0

Amide Bonds 8.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0230156 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAc

Bio-Activity Profile

Function

Antiviral

TargetSARS-CoV-19 UC-1075

Activity20 μM

MethodEC50

RECORD: Rec_0231589 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPivaloylation

C-TermMethyl amidation

Other ModsPivaloylation; Methyl amidation

Bio-Activity Profile

Function

Antiviral Anti-HCMV Entry inhibition

Targetcytomegalovirus (HCMV) AD-169 Strain

Activity20 μM

MethodEC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperPeptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. | Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A. | Int J Mol Sci. 2021 Aug 30;22(17):9427. | DOI:10.3390/ijms22179427 | PMID:34502335 PMID34502335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34502335/

RECORD: Rec_0232520 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcylation

C-TermAmidation

Other ModsAcylation

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV-2 Entry inhibition

TargetSARS-CoV-2 UC-1074 | Vero cells

Activity17.6±2.4 μM

MethodEC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperPeptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. | Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A. | Int J Mol Sci. 2021 Aug 30;22(17):9427. | DOI:10.3390/ijms22179427 | PMID:34502335 PMID34502335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34502335/

RECORD: Rec_0239202 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPivaloylation

C-TermMethyl amidation

Other ModsPivaloylation; Methyl amidation

Bio-Activity Profile

Function

Antiviral Entry inhibition

Targetvaricella-zoster virus (VZV) TK-VZV Strain 07-1

Activity100 μM

MethodEC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperPeptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. | Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A. | Int J Mol Sci. 2021 Aug 30;22(17):9427. | DOI:10.3390/ijms22179427 | PMID:34502335 PMID34502335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34502335/

RECORD: Rec_0244183 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcylation

C-TermMethyl amidation

Other ModsAcylation; Methyl amidation

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV-2 Entry inhibition

TargetSARS-CoV-2 UC-1075 | Vero cells

Activity20 μM

MethodEC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperPeptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. | Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A. | Int J Mol Sci. 2021 Aug 30;22(17):9427. | DOI:10.3390/ijms22179427 | PMID:34502335 PMID34502335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34502335/

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