Peptide Database

Peptide NameSLAY-screened peptide P5151

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC118H171N27O32

DescriptionStandard

        LRHSAELPYSIYSKYQYFTI
    

Molecular Weight2479.78 Da

Isoelectric Point (pI)8.39

Net Charge (pH 7.0)0.85

Net Charge (pH 7.4) 0.58

Charge Density (pH 7.0) 0.0423

GRAVY Index-0.36

Hydrophobic Moment 0.47

Boman Index0.06

Instability Index34.62

Aliphatic Index 83.00

Aromaticity 0.2500

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 966.26

LogP -5.80

H-bond Donors 35.0

H-bond Acceptors 34.0

Rotatable Bonds 76.0

Heavy Atoms 177.0

Ring Count 7.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0186730 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/