Peptide Database

Peptide Name4306(derived from DNA-polymerase domain of HIV-1 RT (20-mers)),53(derived from the HIV-1 HXB2 Pol region of the viral genome)

Function Ontology

Antimicrobial

Antiviral

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC120H203N31O37

DescriptionStandard

        KQLTEAVQKITTEANTISIVIWGK
    

Molecular Weight2672.08 Da

Isoelectric Point (pI)8.50

Net Charge (pH 7.0)0.76

Net Charge (pH 7.4) 0.55

Charge Density (pH 7.0) 0.0318

GRAVY Index-0.01

Hydrophobic Moment 0.66

Boman Index0.10

Instability Index17.01

Aliphatic Index 113.75

Aromaticity 0.0417

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1131.49

LogP -10.48

H-bond Donors 39.0

H-bond Acceptors 38.0

Rotatable Bonds 92.0

Heavy Atoms 188.0

Ring Count 2.0

Amide Bonds 26.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0332692 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

Targetinhibition of strand transfer catalyzed by C130S integrase

Activity2±1 μM

MethodIC50

PaperPeptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase. J Biol Chem. 2005 Jun 10;280(23):21987-21996. doi: 10.1074/jbc.M414679200. PMID: 15790559 PMID15790559;16879966 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15790559/

RECORD: Rec_0390006 VERIFIED: YES