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MYP_008509
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Basic Information
Amp1L, Amp1EP
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
15 amino acids
C90H173N21O16
Standard
Sequence
LKLLKKLLKKLLKLL
Physicochemical Analysis
1805.47 Da
10.70
5.75
5.54
0.3836
0.72
0.81
0.04
-35.95
234.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
626.84
2.37
22.0
22.0
71.0
127.0
0.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0354078 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Stearylation
Amidation
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID23727033 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23727033/
RECORD: Rec_0409941 VERIFIED: YES
Provenance & Taxonomy
Host Defense lytic Peptide [other]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
l=D-Leucine; k=D-Lysine
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 16707464 PMID16707464 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16707464/
RECORD: Rec_0416329 VERIFIED: YES
Provenance & Taxonomy
Host Defense lytic Peptide [other]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
l=D-Leucine; k=D-Lysine
Bio-Activity Profile
Antimicrobial Anticancer
22Rv1
6 μM
LC50
PaperPubMed PMID: 16707464 PMID16707464 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16707464/
RECORD: Rec_0422218 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Amp1EP [(Isopeptide formation: K5, K9, and K13) - Pseudomonas aeruginosa
3.125-6.25 μM
MIC
PMID34043312 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34043312/
RECORD: Rec_0425256 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-negative
Pseudomonas aeruginosa PAO1
PMID26525663;25761937 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26525663/
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