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MYP_008508
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Basic Information
T644
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
36 amino acids
C186H294N52O67
Standard
Sequence
REINNYTSLIHSLIEESQNQQEKNEQELLELDKWAS
Physicochemical Analysis
4330.63 Da
4.42
-5.13
-5.41
-0.1426
-1.20
0.58
-0.23
60.88
89.44
0.0556
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2004.73
-21.64
66.0
63.0
153.0
305.0
4.0
43.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0022536 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
CEM
4.96 μg/mL
IC50
PaperMethods and compositions for treatment of HIV-1 infection using antiviral compounds in simultaneous or sequential combinations PatentUS6861059
RECORD: Rec_0042612 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
human immunodeficiency virus (HIV):inhibition of cell-cell fusion in MT-2 cells
0.001 μM
IC50
PaperPubMed PMID: 17276993 PMID17276993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17276993/
RECORD: Rec_0044608 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 94.4%, E 0.0%, T 0.0%, C 5.6% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0069794 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV Fusion inhibition
Human immunodeficiency virus (HIV) | MT-2 cells
1.47±0.02 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperHIV gp41 C-terminal heptad repeat contains multifunctional domains. Relation to mechanisms of action of anti-HIV peptides | Liu S, Jing W, Cheung B, Lu H, Sun J, Yan X, Niu J, Farmar J, Wu S, Jiang S. | J Biol Chem. 2007 Mar 30;282(13):9612-9620. | DOI:10.1074/jbc.M609148200 | PMID:17276993 PMID17276993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17276993/
RECORD: Rec_0248730 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV
Human immunodeficiency virus (HIV)
2.38±0.035 μM
IC90
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperHIV gp41 C-terminal heptad repeat contains multifunctional domains. Relation to mechanisms of action of anti-HIV peptides | Liu S, Jing W, Cheung B, Lu H, Sun J, Yan X, Niu J, Farmar J, Wu S, Jiang S. | J Biol Chem. 2007 Mar 30;282(13):9612-9620. | DOI:10.1074/jbc.M609148200 | PMID:17276993 PMID17276993 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17276993/
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