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MYP_008501
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Basic Information
pep5-cpp
Anticancer
Antimicrobial
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
20 amino acids
C116H201N43O25
Standard
Sequence
WELVVLGKLYGRKKRRQRRR
Physicochemical Analysis
2598.11 Da
12.00
7.76
7.55
0.3879
-1.45
0.56
-0.69
108.61
87.50
0.1000
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1182.09
-8.91
46.0
33.0
93.0
184.0
3.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001779 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Tat
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Non-standard residue symbol(s): -
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery Anticancer Cytotoxic
HeLa cells; multiple tumor cell lines
50-100 μM
cell death assay
Paperde Araujo CB et al. A novel intracellular peptide derived from G1/S cyclin D2 induces cell death. J Biol Chem. 2014;289:16711-16726. DOI:10.1074/jbc.M113.537118. PMID24764300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24764300/
RECORD: Rec_0047821 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID24764300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24764300/
RECORD: Rec_0387837 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID24764300 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24764300/
RECORD: Rec_0431682 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Tat
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa ATCC 27853
1.56 μM
MIC
PaperSouto BS et al. Pep5-Cpp, a Cyclin D2-Derived Antimicrobial. Molecules. 2026;31(4):634. DOI:10.3390/molecules31040634.
RECORD: Rec_0431683 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Tat
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 29213
6.25 μM
MIC
PaperSouto BS et al. Pep5-Cpp, a Cyclin D2-Derived Antimicrobial. Molecules. 2026;31(4):634. DOI:10.3390/molecules31040634.
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