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MYP_008411
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Basic Information
temporin G
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
13 amino acids
C72H115N17O15
Standard
Sequence
FFPVIGRILNGIL
Physicochemical Analysis
1458.79 Da
9.75
0.76
0.56
0.0585
1.58
0.65
0.58
50.40
172.31
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
508.72
-0.50
17.0
16.0
45.0
104.0
3.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0264049 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Temporin
8407
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-Influenza virus Fusion inhibition
Influenza virus | A549 cells
13 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperTemporin G, an amphibian antimicrobial peptide against influenza and parainfluenza respiratory viruses: Insights into biological activity and mechanism of action. | De Angelis M, Casciaro B, Genovese A, Brancaccio D, Marcocci ME, Novellino E, Carotenuto A, Palamara AT, Mangoni ML, Nencioni L. | FASEB J. 2021 Feb;35(2):e21358. | DOI:10.1096/fj.202001885RR | PMID:33538061 PMID33538061 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33538061/
RECORD: Rec_0285475 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Temporin
8407
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
C-terminal amidated
Bio-Activity Profile
Antimicrobial Antiviral
A. baumannii
12 μM
MIC
PaperTemporins, antimicrobial peptides from the European red frog Rana temporaria.
RECORD: Rec_0342297 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
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