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MYP_008403
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Basic Information
Ranalexin (7-20)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
14 amino acids
C66H121N17O16S3
Standard
Sequence
KIVPAMICAVTKKC
Physicochemical Analysis
1504.97 Da
9.39
2.74
2.50
0.1955
0.99
0.39
0.21
18.61
111.43
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
531.12
-2.97
20.0
22.0
50.0
102.0
1.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0329981 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella pneumoniae
8 μg/mL
MBC
PMID29649587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29649587/
RECORD: Rec_0330389 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
CH3(CH2)12CO, Myristic acid
None
Bio-Activity Profile
Antimicrobial Anticancer
MEC-7
13 μg/mL
IC50
PaperA novel tool against multiresistant bacterial pathogens: lipopeptide modification of the natural antimicrobial peptide ranalexin for enhanced antimicrobial activity and improved pharmacokinetics. Int J Antimicrob Agents. 2018 Jul;52(1):52-62. doi: 10.1016/j.ijantimicag.2018.03.023. PMID: 29649587. PMID29649587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29649587/
RECORD: Rec_0331659 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
CH3(CH2)8CO, Decanoic acid
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
CHO-K1
40 μg/mL
IC50
PaperA novel tool against multiresistant bacterial pathogens: lipopeptide modification of the natural antimicrobial peptide ranalexin for enhanced antimicrobial activity and improved pharmacokinetics. Int J Antimicrob Agents. 2018 Jul;52(1):52-62. doi: 10.1016/j.ijantimicag.2018.03.023. PMID: 29649587. PMID29649587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29649587/
RECORD: Rec_0342046 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Human cervical carcinoma HeLa
33 μg/mL
IC50
PMID29649587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29649587/
RECORD: Rec_0342431 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli O157:H7 ATCC 35150
4 μg/mL
MIC
PMID29649587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29649587/
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