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MYP_008403
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Basic Information
Ranalexin (7-20)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
14 amino acids
C66H121N17O16S3
Standard
Sequence
KIVPAMICAVTKKC
Physicochemical Analysis
1504.97 Da
9.39
2.74
2.50
0.1955
0.99
0.39
0.21
18.61
111.43
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
531.12
-2.97
20.0
22.0
50.0
102.0
1.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0021086 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Enterococcus faecium
16 μg/mL
MIC
PMID29649587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29649587/
RECORD: Rec_0021179 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis DSM 10
4 μg/mL
MBC
PMID29649587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29649587/
RECORD: Rec_0021437 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus megaterium DSM 32
4 μg/mL
MBC
PMID29649587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29649587/
RECORD: Rec_0022922 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
CH3(CH2)12CO, Myristic acid
None
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
36 μg/mL
IC50
PaperA novel tool against multiresistant bacterial pathogens: lipopeptide modification of the natural antimicrobial peptide ranalexin for enhanced antimicrobial activity and improved pharmacokinetics. Int J Antimicrob Agents. 2018 Jul;52(1):52-62. doi: 10.1016/j.ijantimicag.2018.03.023. PMID: 29649587. PMID29649587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29649587/
RECORD: Rec_0023319 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
CH3(CH2)11CO, Tridecanoic acid
None
Bio-Activity Profile
Antimicrobial Anticancer
HepG2
18 μg/mL
IC50
PaperA novel tool against multiresistant bacterial pathogens: lipopeptide modification of the natural antimicrobial peptide ranalexin for enhanced antimicrobial activity and improved pharmacokinetics. Int J Antimicrob Agents. 2018 Jul;52(1):52-62. doi: 10.1016/j.ijantimicag.2018.03.023. PMID: 29649587. PMID29649587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29649587/
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