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MYP_008403
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Basic Information
Ranalexin (7-20)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
14 amino acids
C66H121N17O16S3
Standard
Sequence
KIVPAMICAVTKKC
Physicochemical Analysis
1504.97 Da
9.39
2.74
2.50
0.1955
0.99
0.39
0.21
18.61
111.43
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
531.12
-2.97
20.0
22.0
50.0
102.0
1.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0184306 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
CH3(CH2)11CO, Tridecanoic acid
None
Bio-Activity Profile
Antimicrobial Anticancer
HepG2
19 μg/mL
IC50
PaperA novel tool against multiresistant bacterial pathogens: lipopeptide modification of the natural antimicrobial peptide ranalexin for enhanced antimicrobial activity and improved pharmacokinetics. Int J Antimicrob Agents. 2018 Jul;52(1):52-62. doi: 10.1016/j.ijantimicag.2018.03.023. PMID: 29649587. PMID29649587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29649587/
RECORD: Rec_0186601 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
CH3(CH2)12CO, Myristic acid
None
Bio-Activity Profile
Antimicrobial Anticancer
HepG2
32 μg/mL
IC50
PaperA novel tool against multiresistant bacterial pathogens: lipopeptide modification of the natural antimicrobial peptide ranalexin for enhanced antimicrobial activity and improved pharmacokinetics. Int J Antimicrob Agents. 2018 Jul;52(1):52-62. doi: 10.1016/j.ijantimicag.2018.03.023. PMID: 29649587. PMID29649587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29649587/
RECORD: Rec_0186671 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Acinetobacter baumannii
02-4 μg/mL
MIC
PMID29649587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29649587/
RECORD: Rec_0188419 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
CH3(CH2)9CO, Undecanoic acid
None
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
36 μg/mL
IC50
PaperA novel tool against multiresistant bacterial pathogens: lipopeptide modification of the natural antimicrobial peptide ranalexin for enhanced antimicrobial activity and improved pharmacokinetics. Int J Antimicrob Agents. 2018 Jul;52(1):52-62. doi: 10.1016/j.ijantimicag.2018.03.023. PMID: 29649587. PMID29649587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29649587/
RECORD: Rec_0189340 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis DSM 10
8 μg/mL
MIC
PMID29649587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29649587/
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