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MYP_008402
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Basic Information
P16
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition
Standard
12 amino acids
C68H101N15O17S
Standard
Sequence
GTKWLTEVWPLC
Physicochemical Analysis
1432.68 Da
5.99
-0.25
-0.47
-0.0207
0.14
0.43
0.28
28.43
89.17
0.1667
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
509.99
-1.25
19.0
18.0
41.0
101.0
5.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016246 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
14±4 μM
KI
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperA new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility. | Agopian A, Gros E, Aldrian-Herrada G, Bosquet N, Clayette P, Divita G. | J Biol Chem. 2009 Jan 2;284(1):254-264. | DOI:10.1074/jbc.M802199200 | PMID:18952602 PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0110881 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of polymerase activity of HIV-1 RT(Ki =14 ± 4 μM)
PaperA New Generation of Peptide-based Inhibitors Targeting HIV-1 Reverse Transcriptase Conformational Flexibility PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0115105 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperA New Generation of Peptide-based Inhibitors Targeting HIV-1 Reverse Transcriptase Conformational Flexibility PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0192490 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Reverse transcriptase inhibition
HeLa
14±4 μM
Ki
PaperA new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility. PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0242202 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/