Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length442 amino acids

Chemical FormulaC2241H3541N605O621S10

DescriptionStandard

        TNPGFVVRITQAGLDYAHQQGIAVLEKELAQLKMPDISGDFRIRRVGKVRYEISRLDLRRFHLPYSRISLVPNVGLQVSISNAFAEVDGNWRVKIHFIRDHGSFDLKVENIYIKINLKLGSDTSGKPTIDTSDCSTRISKVRVHFSGKFGWLYNLFHSAIESRFRKILESKVCENVVSSVRRELQPYLRTLPVTARIDAMAGIDYSLVAPPTTTAQSLDVDLKGEFFSLAHRSAVPFPPLALAFPPDHDRMVYFGASSYFFNTASFAYHGAGALVFEITDSLIPKDIDFHLNTSTFSAFIPQLEKMYPDMLMKFRLSASSAPFLNIGPGGLSLKPVVDIQAYAILPNSSLAPLFLLSLVSNVSAVIDVKSGHIVGSLKVGRMKLSLKHSDVGTFQVRTLQSIMNILASSILLPRLNARLDQGFPLPLPDRIQLSNILVRFHQ
    

Molecular Weight49215.42 Da

Isoelectric Point (pI)9.59

Net Charge (pH 7.0)12.54

Net Charge (pH 7.4) 11.58

Charge Density (pH 7.0) 0.0284

GRAVY Index0.08

Hydrophobic Moment 0.72

Boman Index0.09

Instability Index36.77

Aliphatic Index 103.21

Aromaticity 0.0950

Extinction Coeff. Reduced 28880.00

Extinction Coeff. Oxidized 29005.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0136562 VERIFIED: NO

Provenance & Taxonomy

OrganismSpheniscus mendiculus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence