Peptide Database

Peptide NameSynenkephalin

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length73 amino acids

Chemical FormulaC352H571N95O115S7

DescriptionStandard

        ECSQDCATCSYRLVRPADINFLACVMECEGKLPSLKIWETCKELLQLSKPELPQDGTSTLRENSKPEESHLLA
    

Molecular Weight8198.32 Da

Isoelectric Point (pI)4.84

Net Charge (pH 7.0)-4.12

Net Charge (pH 7.4) -4.45

Charge Density (pH 7.0) -0.0564

GRAVY Index-0.40

Hydrophobic Moment 0.61

Boman Index-0.07

Instability Index56.18

Aliphatic Index 82.88

Aromaticity 0.0411

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3380.65

LogP -35.04

H-bond Donors 120.0

H-bond Acceptors 119.0

Rotatable Bonds 274.0

Heavy Atoms 569.0

Ring Count 10.0

Amide Bonds 77.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0073439 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyOpioid

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Opioid Analgesic Neuromodulator

RECORD: Rec_0222980 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0223607 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilySynenkephalin

Tax ID9606

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide2-24; 6-28; 9-41

Bio-Activity Profile

Function

Analgesic Pronociceptive Hormone Endocrine Neuropeptide Neuromodulator Growth regulation Development regulation Receptor modulation

Half-LifeMammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour