Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length464 amino acids

Chemical FormulaC2385H3738N610O667S15

DescriptionStandard

        MCTKMVQVLWGCFLLWNLYISSAQTIYPGIKARATQRALDYGIQAGVEMIEQMVKERKIPDLKGSESPKFLKIDYMNYKLINIKINAFSLPNTSLAFVPGVGIRALIKHGTANISTDWEIKSPLFQDTGGANLLLSGVYFTGILVLARNDFGHPILKLQDCNAQVSRNDISFSGELSVLYNSFAEPMEKPILKNLNKMLCPIITSEVEALNANLSMLEVLRSVDNYTLLDYSLISSPEITENYIDLNLKGVFYPLENLTDPPFSSVPFVLPEHNDSMIYIGISEYFFKSASYAYFTAGAFNVTLTTKKIFNHLIRNSQGLGNMLSWVASTNVALAILGQRLICSLSLNRFRLSLPESIRSNIEVFRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYKTSLKQQSSFHGWEALNLIRGRWRGKPAPWLPVWSPLQEVNRP
    

Molecular Weight52109.85 Da

Isoelectric Point (pI)8.61

Net Charge (pH 7.0)4.10

Net Charge (pH 7.4) 3.35

Charge Density (pH 7.0) 0.0088

GRAVY Index0.08

Hydrophobic Moment 0.71

Boman Index0.14

Instability Index45.14

Aliphatic Index 106.12

Aromaticity 0.1034

Extinction Coeff. Reduced 67840.00

Extinction Coeff. Oxidized 68090.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0317962 VERIFIED: NO

Provenance & Taxonomy

OrganismTursiops truncatus [Animal]

FamilyBPI

Tax ID9739

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence