Peptide Database

Peptide NameTachykinin-2

Function Ontology

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Tachykinin peptide

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC57H91N13O18S

DescriptionStandard

        KPPSSSEFVGLM
    

Molecular Weight1278.47 Da

Isoelectric Point (pI)6.00

Net Charge (pH 7.0)-0.24

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0198

GRAVY Index-0.06

Hydrophobic Moment 0.17

Boman Index0.16

Instability Index76.06

Aliphatic Index 56.67

Aromaticity 0.0833

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 489.85

LogP -4.96

H-bond Donors 16.0

H-bond Acceptors 19.0

Rotatable Bonds 39.0

Heavy Atoms 89.0

Ring Count 3.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0052061 VERIFIED: YES

Provenance & Taxonomy

OrganismOctopus vulgaris [Animal]

FamilyTachykinin

Tax ID6645

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Tissue-contractile activity Neuropeptide

Targetcarp rectum; guinea-pig ileum

Methodisolated tissue contraction assay

Half-LifeMammalian: 1.3 hour; Yeast: 3 min; E. coli: 2 min

RECORD: Rec_0091230 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0217624 VERIFIED: NO

Provenance & Taxonomy

OrganismOctopus vulgaris [Animal]

FamilyTachykinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0431674 VERIFIED: YES

Provenance & Taxonomy

OrganismOctopus vulgaris [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Tissue-contractile activity Neuropeptide

TargetRattus norvegicus ileum

Methodisolated tissue contractility assay

RECORD: Rec_0431675 VERIFIED: YES

Provenance & Taxonomy

OrganismOctopus vulgaris [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Tissue-contractile activity Neuropeptide

TargetProcambarus clarkii hindgut

Methodisolated tissue contractility assay