Peptide Database

Peptide NameOC43-HR2P

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross

Standard StatusStandard

Sequence Length36 amino acids

Chemical FormulaC190H306N48O61S

DescriptionStandard

        SLDYINVTFLDLQDEMNRLQEAIKVLNQSYINLKDI
    

Molecular Weight4270.81 Da

Isoelectric Point (pI)4.23

Net Charge (pH 7.0)-3.53

Net Charge (pH 7.4) -3.75

Charge Density (pH 7.0) -0.0982

GRAVY Index-0.19

Hydrophobic Moment 0.60

Boman Index0.01

Instability Index42.64

Aliphatic Index 127.22

Aromaticity 0.0833

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1822.34

LogP -15.14

H-bond Donors 60.0

H-bond Acceptors 59.0

Rotatable Bonds 148.0

Heavy Atoms 300.0

Ring Count 3.0

Amide Bonds 42.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0416754 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermPEG8-K(Chol)

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

TargetMERS-CoV:inhibition of pseudovirus infection in Huh-7 cells

Activity0.0052±0.0005 μM

MethodIC50

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