Peptide Database

Peptide NameSLAY-screened peptide P997

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC118H169N37O29S

DescriptionStandard

        RRYLRFSGYYLHSTHNKCHY
    

Molecular Weight2601.90 Da

Isoelectric Point (pI)9.86

Net Charge (pH 7.0)4.01

Net Charge (pH 7.4) 3.63

Charge Density (pH 7.0) 0.2003

GRAVY Index-1.27

Hydrophobic Moment 0.60

Boman Index-0.32

Instability Index107.88

Aliphatic Index 39.00

Aromaticity 0.2500

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1098.68

LogP -9.64

H-bond Donors 43.0

H-bond Acceptors 37.0

Rotatable Bonds 81.0

Heavy Atoms 185.0

Ring Count 8.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0246286 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/