Peptide Database

Peptide Name#5654 derived from HIV-1 integrase

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC77H120N20O22S

DescriptionStandard

        PGIWQLDCTHLEGKI
    

Molecular Weight1709.96 Da

Isoelectric Point (pI)5.33

Net Charge (pH 7.0)-0.96

Net Charge (pH 7.4) -1.09

Charge Density (pH 7.0) -0.0641

GRAVY Index-0.17

Hydrophobic Moment 0.22

Boman Index0.17

Instability Index14.09

Aliphatic Index 104.00

Aromaticity 0.0667

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 665.14

LogP -4.21

H-bond Donors 24.0

H-bond Acceptors 23.0

Rotatable Bonds 55.0

Heavy Atoms 120.0

Ring Count 4.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0178912 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Replication inhibition

TargetHIV-1

Activity30 μM

Method% inhibition

Half-LifeMammalian: >20 h; Yeast: >20 h; E. coli: ?

PaperInhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase. | Oz Gleenberg I, Herschhorn A, Goldgur Y, Hizi A. | Arch Biochem Biophys. 2007 Feb 15;458(2):202-12. | DOI:10.1016/j.abb.2006.12.007 | PMID:17257575 PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/

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