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MYP_008040
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Basic Information
#5654 derived from HIV-1 integrase
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition
Standard
15 amino acids
C77H120N20O22S
Standard
Sequence
PGIWQLDCTHLEGKI
Physicochemical Analysis
1709.96 Da
5.33
-0.96
-1.09
-0.0641
-0.17
0.22
0.17
14.09
104.00
0.0667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
665.14
-4.21
24.0
23.0
55.0
120.0
4.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0028934 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1: inhibition of reverse transcriptase(RNA-dependent DNA polymerase) activity(62.5 ± 0.5% residual DNA polymerase activity at 30 μM)
PaperPubMed PMID: 17257575 PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
RECORD: Rec_0089938 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 17257575 PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
RECORD: Rec_0095236 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1[60-70% RT activity = 30 microM
PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
RECORD: Rec_0134181 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0152717 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Reverse transcriptase inhibition
Qualitative inhibition
PaperInhibition of human immunodeficiency virus type-1 reverse transcriptase by a novel peptide derived from the viral integrase. PMID17257575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17257575/
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