MYP_007973
papuamide A
Anticancer
Antimicrobial
not Standard
12 amino acids
-
contains X representing unresolved or non-standard residue
XGTXXXXXXAGX
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
RECORD: Rec_0040865
VERIFIED: YES
Provenance & Taxonomy
not reported [other]
papuamide
Structure & Mods
side-chain cyclized peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Fatty acylation (aC11:2(4.6)-Me(2.6)-OH(2.3))
Non-proteinogenic/modified monomers: L-Dbu; 3Me-4Me-Gln; 3OH-Leu; Hpr; bOMe-Tyr; NMe-Thr; D-3OMe-Ala
Bio-Activity Profile
HIV-1 entry inhibition
Anticancer
Cytotoxic
Antimicrobial
HIV-1 RF; human T-lymphoblastoid cells
4 ng/mL
EC50
RECORD: Rec_0351036
VERIFIED: YES
Provenance & Taxonomy
not reported [other]
papuamide
Structure & Mods
side-chain cyclized peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Fatty acylation (aC11:2(4.6)-Me(2.6)-OH(2.3))
Non-proteinogenic/modified monomers: dhAbu; 3Me-4Me-Gln; 3OH-Leu; Hpr; bOMe-Tyr; NMe-Thr; D-3OMe-Ala
Bio-Activity Profile
HIV-1 entry inhibition
Antimicrobial
HIV-1
viral entry inhibition assay
RECORD: Rec_0431672
VERIFIED: YES
Provenance & Taxonomy
Structure & Mods
side-chain cyclized peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Non-proteinogenic/modified monomers: L-Dbu; 3Me-4Me-Gln; 3OH-Leu; Hpr; bOMe-Tyr; NMe-Thr; D-3OMe-Ala
Bio-Activity Profile
Anticancer
Cytotoxic
human cancer cell line panel
75 ng/mL
mean IC50 cytotoxicity assay