Peptide Database

Peptide NameAntimicrobial peptide Pxt-3

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antiparasitic ▸ Antiprotozoal

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxicity

Standard StatusStandard

Sequence Length23 amino acids

Chemical FormulaC106H173N29O30

DescriptionStandard

        GLKEVAHSAKKFAKGFISGLTGS
    

Molecular Weight2333.68 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)2.85

Net Charge (pH 7.4) 2.59

Charge Density (pH 7.0) 0.1237

GRAVY Index0.01

Hydrophobic Moment 0.66

Boman Index0.13

Instability Index-5.20

Aliphatic Index 76.52

Aromaticity 0.0870

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 954.50

LogP -10.37

H-bond Donors 34.0

H-bond Acceptors 34.0

Rotatable Bonds 81.0

Heavy Atoms 165.0

Ring Count 3.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0374896 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

Tax ID8364

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Cytotoxic

TargetCytotoxicity against T-lymphocytes

Activity256 μM

MethodIC50

RECORD: Rec_0379345 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

Tax ID8364

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetGram-negative bacteria: Escherichia coli DH5α(Not active up to 150 μg/ml)

RECORD: Rec_0383514 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

FamilyMagainin

Tax ID8364

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antiparasitic

TargetEscherichia coli

Activity64 μM

MethodMIC

RECORD: Rec_0396770 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

Tax ID8364

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetStaphylococcus aureus JCM 2151(Not active up to 150 μg/ml)

RECORD: Rec_0398624 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

Tax ID8364

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

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