Peptide Database

Peptide NameI-3

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC112H192N30O20

DescriptionStandard

        LVKRFKKFFRKLKKSVLL
    

Molecular Weight2278.91 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)7.75

Net Charge (pH 7.4) 7.54

Charge Density (pH 7.0) 0.4308

GRAVY Index-0.07

Hydrophobic Moment 0.95

Boman Index-0.24

Instability Index8.17

Aliphatic Index 118.89

Aromaticity 0.1667

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 858.17

LogP -1.84

H-bond Donors 32.0

H-bond Acceptors 28.0

Rotatable Bonds 84.0

Heavy Atoms 162.0

Ring Count 3.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0338049 VERIFIED: YES

Provenance & Taxonomy

Organismcationic host defense peptides [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/

RECORD: Rec_0372107 VERIFIED: YES

Provenance & Taxonomy

Organismcationic host defense peptides [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetMCF-7/Taxol

Activity10.3±0.3 μM

MethodIC50

PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/

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