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MYP_007921
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Basic Information
Spinigerin (Insects, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C136H247N41O32S
Standard
Sequence
HVDKKVADKVLLLKQLRIMRLLTRL
Physicochemical Analysis
3000.74 Da
11.07
4.85
4.58
0.1938
0.16
0.74
-0.14
-2.64
163.60
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1218.10
-5.99
44.0
39.0
109.0
210.0
1.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0301778 VERIFIED: YES
Provenance & Taxonomy
Pseudacanthotermes spiniger [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Fusarium culmorum
PMID11053427;16170803 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11053427/
RECORD: Rec_0310077 VERIFIED: YES
Provenance & Taxonomy
Pseudacanthotermes spiniger [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Pseudomonas aeruginosa
PMID11053427;16170803 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11053427/
RECORD: Rec_0313573 VERIFIED: YES
Provenance & Taxonomy
Pseudacanthotermes spiniger [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa
50-100 μM
MIC
PMID20692130;12963031 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20692130/
RECORD: Rec_0328508 VERIFIED: YES
Provenance & Taxonomy
Pseudacanthotermes spiniger [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli KCTC 1682
16 μM
MIC
PMID20692130;12963031 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20692130/
RECORD: Rec_0347964 VERIFIED: YES
Provenance & Taxonomy
Pseudacanthotermes spiniger [Animal]
Spinigerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral
PaperJ. Biol. Chem. 2001; 276:4085-4092 | http://www.ncbi.nlm.nih.gov/pubmed/11053427 PMID11053427 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11053427/
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