Peptide Database

Peptide Name[2,8]-cis dicarba alpha-conotoxin RgIA

Function Ontology

Miscellaneous

Standard Statusnot Standard

Sequence Length13 amino acids

Chemical Formula-

Descriptioncontains X representing unresolved or non-standard residue

        GXCSDPRXRYRCR
    

Molecular Weight0.00 Da

Isoelectric Point (pI)0.00

Net Charge (pH 7.0)0.00

GRAVY Index0.00

Boman Index0.00

Instability Index0.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0382340 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermNone

Other Mods2,8-cis dicarba bridge (non-reducible carbabridge)

Bio-Activity Profile

Function

N-type calcium channel inhibitor Ion-channel modulator Toxin-derived

Targethuman Cav2.2 (N-type voltage-gated calcium channel); GABAB receptor pathway

Methodwhole-cell electrophysiology / N-type calcium current inhibition assay

PaperConoServer: updated content, knowledge, and discovery tools in the conopeptide database; Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets. J Med Chem. 2014. DOI:10.1021/JM501126U PMID22058133;25393758 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22058133/