Peptide Database

Peptide NameSLAY-screened peptide P1843

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC90H142N34O33

DescriptionStandard

        LNFSAVRQDGTHRTSSNSNH
    

Molecular Weight2228.30 Da

Isoelectric Point (pI)9.61

Net Charge (pH 7.0)0.94

Net Charge (pH 7.4) 0.63

Charge Density (pH 7.0) 0.0468

GRAVY Index-1.26

Hydrophobic Moment 0.30

Boman Index-0.32

Instability Index26.63

Aliphatic Index 39.00

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1128.42

LogP -19.24

H-bond Donors 40.0

H-bond Acceptors 36.0

Rotatable Bonds 73.0

Heavy Atoms 157.0

Ring Count 3.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0361422 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/