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MYP_007850
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Basic Information
SpPR-AMP1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
37 amino acids
C219H301N59O41
Standard
Sequence
GYFPGRPPFPRPFPRPPSRPFPRPPFPGPFPRPYPWR
Physicochemical Analysis
4416.10 Da
12.00
6.76
6.55
0.1826
-1.28
0.78
-0.16
116.36
0.00
0.2432
8480.00
8480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1471.27
-6.74
46.0
48.0
103.0
319.0
27.0
36.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0242701 VERIFIED: YES
Provenance & Taxonomy
Scylla paramamosain [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Vibrio harveyi
0.195
MIC
PMID28479344 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28479344/
RECORD: Rec_0299081 VERIFIED: YES
Provenance & Taxonomy
Scylla paramamosain [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 35218
12.5
MIC
PMID28479344 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28479344/
RECORD: Rec_0307533 VERIFIED: YES
Provenance & Taxonomy
Scylla paramamosain [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Salmonella thyphimurium ATCC 13311
3.13
MIC
PMID28479344 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28479344/
RECORD: Rec_0310082 VERIFIED: YES
Provenance & Taxonomy
Scylla paramamosain [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
50 μM
MIC
PMID28479344 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28479344/
RECORD: Rec_0325487 VERIFIED: YES
Provenance & Taxonomy
Scylla paramamosain [Animal]
PrAMP
85552
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
C219H302N59O41; Mol Wt 4416.181; GRAVY= -1.28; Wimley-White whole-residue hydrophobicity of the peptide: 2.97 kcal/mol. A synthetic form is active against M. luteus ATCC9341 (MIC 0.78-1.56 uM), S. Typhimurium ATCC13311 (MIC 3.1-6.2 uM), E. coli ATCC35218 (MIC 12.5-25 uM), V. harveyi (MIC 0.195-0.39 uM), and V. parahaemolyticus ATCC17802 (MIC 3.1-6.2 uM). Recombinant peptide only showed activity against M. luteus ATCC9341 (MIC 3.1-6.2 uM) and V. harveyi (MIC 1.56-3.13 uM). The reasons may be multiple and a possible sequence modification cannot not be excluded
Bio-Activity Profile
Antimicrobial
Micrococcus luteus ATCC 9341
3.1-6.2 μM
MIC
PaperCharacterization and antimicrobial evaluation of SpPR-AMP1, a proline-rich antimicrobial peptide from the mud crab Scylla paramamosain.
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