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MYP_007787
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Basic Information
WQ-SY(628-655)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
28 amino acids
C163H250N40O52
Standard
Sequence
WEEWDKKIEEYTKKIEELIKKSQNQQSY
Physicochemical Analysis
3601.97 Da
5.19
-1.23
-1.46
-0.0439
-1.83
0.69
-0.38
82.19
55.71
0.1429
13980.00
13980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1571.33
-11.51
53.0
51.0
129.0
255.0
6.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0169422 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1 IIIB:inhibition of virus infection in MT-2 cells
0.0548 μM
IC50
PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/
RECORD: Rec_0272741 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 IIIB | MT-2 cells
0.0548 μM
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperCreating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors. | Su S, Zhu Y, Ye S, Qi Q, Xia S, Ma Z, Yu F, Wang Q, Zhang R, Jiang S, Lu L. | J Virol. 2016 Dec 16;91(1):e01445-16. | DOI:10.1128/JVI.01445-16 | PMID:27795416 PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/
RECORD: Rec_0382156 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 IIIB
PMID27795416 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795416/