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MYP_007777
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Basic Information
Japonicin-2 (Frogs, amphibians, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
21 amino acids
C110H193N27O23S3
Standard
Sequence
FGLPMLSILPKALCILLKRKC
Physicochemical Analysis
2358.07 Da
9.85
3.74
3.50
0.1780
1.08
0.52
0.27
54.10
153.33
0.0476
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
787.93
-1.38
29.0
30.0
79.0
163.0
3.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0045932 VERIFIED: YES
Provenance & Taxonomy
Rana japonica [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
14-21
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
20 μM
MIC
PMID11835990 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11835990/
RECORD: Rec_0070454 VERIFIED: YES
Provenance & Taxonomy
Rana japonica [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
14-21
Bio-Activity Profile
Antimicrobial
Escherichia coli
12 μM
MIC
PaperAntimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica.
RECORD: Rec_0111152 VERIFIED: YES
Provenance & Taxonomy
Rana japonica [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
20 μM
MIC
PMID11835990 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11835990/
RECORD: Rec_0114654 VERIFIED: YES
Provenance & Taxonomy
Rana japonica [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0182284 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
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