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MYP_007773
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Basic Information
HmdSL-37 (cathelicidin; primates, mammals, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
37 amino acids
C204H334N62O51
Standard
Sequence
SLGNFFRKARKKIGEEFKRIVQRIKDFLQHLIPRTEA
Physicochemical Analysis
4471.22 Da
11.00
5.55
5.28
0.1500
-0.68
0.89
-0.26
17.17
87.03
0.1081
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1889.34
-14.61
67.0
58.0
158.0
317.0
6.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0288890 VERIFIED: YES
Provenance & Taxonomy
Hylobates moloch [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0301774 VERIFIED: YES
Provenance & Taxonomy
Hylobates moloch [Animal]
Cathelicidin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
In 20% TSB in SPB medium Escherichia coli
2 μM
MIC
PMID16720578 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16720578/
RECORD: Rec_0318614 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 73.0%, E 0.0%, T 5.4%, C 21.6% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0340198 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli (MIC 2 uM, 20% TSB in SPB; 1 uM, 5% TSB in SPB; >32 uM, 20TSB in PIL), Pseudomonas aeruginosa (MIC 8 uM, 20% TSB in SPB; 2 uM, 5% TSB in SPB; 16-32 uM, 20TSB in PIL), Staphylococcus aureus (MIC >32 uM, 20% TSB in SPB; 8-16 uM, 5% TSB in SPB; 32 uM, 20TSB in PIL), Enterococcus faecalis (MIC 8, 20% TSB in SPB; >32 uM, 20TSB in PIL), Candida albicans (MIC >32 uM, 20% TSB in SPB; 8 uM, 5% TSB in SPB; >32 uM, 20TSB in PIL). UPdated 7/2021
PaperEvolution of the primate cathelicidin: correlation between structural variations and antimicrobial activity
RECORD: Rec_0362132 VERIFIED: YES
Provenance & Taxonomy
Hylobates sp. [Animal]
Cathelicidin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Pseudomonas aeruginosa
2 μM
MIC
PMID16720578 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16720578/
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