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MYP_007715
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Basic Information
Unnamed
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Standard
7 amino acids
C41H57N11O10
Standard
Sequence
EWLGGRF
Physicochemical Analysis
863.96 Da
6.10
-0.16
-0.33
-0.0233
-0.44
0.33
0.11
22.36
55.71
0.2857
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
352.91
-1.29
13.0
10.0
26.0
62.0
3.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0109353 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamylation
Amidation
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0161177 VERIFIED: NO
Provenance & Taxonomy
Hydra vulgaris [Animal]
Hydra-RFamide
6087
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamylation
Amidation
Bio-Activity Profile
-
Mammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Hydra-RFamide 1 (Hydra vulgaris): PMID 8954943 PMID8954943 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8954943/
RECORD: Rec_0431637 VERIFIED: NO
Provenance & Taxonomy
Structure & Mods
Bio-Activity Profile
-
RECORD: Rec_0431639 VERIFIED: YES
Provenance & Taxonomy
Hydra vulgaris [Animal]
FMRFamide related peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamylation
Amidation
Bio-Activity Profile
RFamide Neuropeptide Neuromodulator Ion-channel activation
HyNaC2/3/5
3.48±0.55 μM
EC50 (Xenopus oocyte electrophysiology)
PaperThe comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission PMID25312679
RECORD: Rec_0431640 VERIFIED: YES
Provenance & Taxonomy
Hydra vulgaris [Animal]
FMRFamide related peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamylation
Amidation
Bio-Activity Profile
RFamide Neuropeptide Neuromodulator Ion-channel activation
HyNaC2/11/5
13.8±1.9 μM
EC50 (Xenopus oocyte electrophysiology)
PaperThe comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission PMID25312679
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