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MYP_007690
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Basic Information
RJ6
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C107H196N34O22
Standard
Sequence
AKKAAKKAKKAAKKAKKWAKK
Physicochemical Analysis
2310.92 Da
11.04
11.78
11.58
0.5611
-1.59
0.72
-0.58
2.37
38.10
0.0476
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
973.35
-7.47
35.0
34.0
91.0
163.0
2.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001753 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 15498607 PMID15498607 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15498607/
RECORD: Rec_0005408 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Herpes simplex virus 1 (Replication); MRC-5
47.3 μM
Plaque assay
PaperA wide range of medium-sized, highly cationic, alpha-helical peptides show antiviral activity against herpes simplex virus. | Jenssen H, Andersen JH, Mantzilas D, Gutteberg TJ. | Antiviral Res. 2004 | PMID:15498607 PMID15498607 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15498607/
RECORD: Rec_0109998 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
human fibroblasts(MRC-5 cells)
433 μM
CC50
PaperPubMed PMID: 15498607 PMID15498607 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15498607/
RECORD: Rec_0129375 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
herpes simplex virus 1(HSV-1):inhibition of HSV-1 infection in MRC-5 cells
47.3 μM
IC50
PaperPubMed PMID: 15498607 PMID15498607 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15498607/
RECORD: Rec_0266085 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
herpes simplex virus 1 (HSV-1) | MRC-5 cells
47.3 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperA wide range of medium-sized, highly cationic, alpha-helical peptides show antiviral activity against herpes simplex virus. | Jenssen H, Andersen JH, Mantzilas D, Gutteberg TJ. | Antiviral Res. 2004 Nov;64(2):119-26. | DOI:10.1016/j.antiviral.2004.08.003 | PMID:15498607 PMID15498607 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15498607/
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