Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC164H269N65O39S6

DescriptionStandard

        GICRCICGRGICRCICGRIGGRVPGVGVPGVGHHHHHH
    

Molecular Weight3967.69 Da

Isoelectric Point (pI)9.30

Net Charge (pH 7.0)5.22

Net Charge (pH 7.4) 4.63

Charge Density (pH 7.0) 0.1375

GRAVY Index0.14

Hydrophobic Moment 0.66

Boman Index0.08

Instability Index11.95

Aliphatic Index 81.84

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1604.02

LogP -18.79

H-bond Donors 64.0

H-bond Acceptors 56.0

Rotatable Bonds 125.0

Heavy Atoms 274.0

Ring Count 8.0

Amide Bonds 37.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0311485 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 26.3%, E 0.0%, T 23.7%, C 50.0% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Antimicrobial

RECORD: Rec_0331015 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsRecombinant construct with C-terminal His6 tag; Backbone-cyclized theta-defensin scaffold

Bio-Activity Profile

Function

Antiviral Protease inhibitor Replication inhibitor

TargetDengue 2 virus (Replication); Vero

Activity21.4 μM

MethodPlaque assay