Peptide Database

Peptide NameRanatuerin-2P (Ranatuerin 2P; Frogs, amphibians, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antiviral

Standard StatusStandard

Sequence Length27 amino acids

Chemical FormulaC126H222N36O36S4

DescriptionStandard

        LMDTVKNVAKNLAGHMLDKLKCKITGC
    

Molecular Weight2945.59 Da

Isoelectric Point (pI)9.24

Net Charge (pH 7.0)2.82

Net Charge (pH 7.4) 2.53

Charge Density (pH 7.0) 0.1046

GRAVY Index0.06

Hydrophobic Moment 0.65

Boman Index0.02

Instability Index-12.73

Aliphatic Index 101.11

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1179.94

LogP -10.71

H-bond Donors 42.0

H-bond Acceptors 44.0

Rotatable Bonds 105.0

Heavy Atoms 202.0

Ring Count 1.0

Amide Bonds 28.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0344642 VERIFIED: YES

Provenance & Taxonomy

OrganismRana pipiens [Animal]

FamilyRanatuerin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli

Activity13 μM

MethodMIC

RECORD: Rec_0345600 VERIFIED: YES

Provenance & Taxonomy

OrganismRana pipiens [Animal]

FamilyRanatuerin

Structure & Mods

Configstapled cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide22-27

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral

TargetVirus

RECORD: Rec_0361273 VERIFIED: YES

Provenance & Taxonomy

OrganismRana pipiens [Animal]

FamilyRanatuerin

Structure & Mods

Configstapled cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide22-27

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral

RECORD: Rec_0377639 VERIFIED: YES

Provenance & Taxonomy

OrganismRana pipiens [Animal]

FamilyRanatuerin

Structure & Mods

Configstapled cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide22-27

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral

TargetFrog Virus 3

Activity90 % inhibition

MethodAntiviral inhibition assay

RECORD: Rec_0379734 VERIFIED: YES

Provenance & Taxonomy

OrganismRana pipiens [Animal]

FamilyRanatuerin

Structure & Mods

Configstapled cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide22-27

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiviral

TargetStaphylococcus aureus

Activity50 μM

MethodMIC

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