Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length481 amino acids

Chemical FormulaC2446H3870N640O679S21

DescriptionStandard

        MAWGPDNVRKWSTLALLAIMGTALTAAVNPGFVAIIYQEGLNFACREAVAVLQKELQTIKVPDFSGVFKIKHLGRGYYDFYSMAVDGFHIPNPQISSLPTDGLQLSIQNADIKISGKWKSRKNFLKASGKFDLDVQGVSISADLRLGRNPSGHITVQCSACNSHIDSVHVKISGSMLGWLIQLFHKNIETSLRNTIYQKICTIVINSVSTKLQPYVQTLPVIARVDEMVAIDYSLLTVTTTPELLEGQLKGEFFWRGHRSPLPIIPPAMNFSPNNNRMLHLVISDYFFNTAGFAYHESGILKITLRDQMLPKDSKFRLNTEFLGTFLPKVAMMFPSTEVQLVISTFSPPRLSIQPSGLLLDLAMKTQAFSVLANSSLVPLFLLHINTNASLEVDFEANRLVGEMKLEKLMLELKQSDFGSFKVELMEAAINYLMPKMVLPRINERLRRGFPLPLPAGVQLNNLMFQSYENFLVLGADIHRT
    

Molecular Weight53780.14 Da

Isoelectric Point (pI)9.06

Net Charge (pH 7.0)7.46

Net Charge (pH 7.4) 6.53

Charge Density (pH 7.0) 0.0155

GRAVY Index0.10

Hydrophobic Moment 0.80

Boman Index0.13

Instability Index36.67

Aliphatic Index 102.56

Aromaticity 0.0915

Extinction Coeff. Reduced 43890.00

Extinction Coeff. Oxidized 44140.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0239491 VERIFIED: NO

Provenance & Taxonomy

OrganismMesocricetus auratus [Animal]

FamilyBPI/LBP

Tax ID10036

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria