Peptide Database

Peptide NameSLAY-screened peptide P4174

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC103H160N24O29S3

DescriptionStandard

        DHLPVVTLYSMLSCHSYCLL
    

Molecular Weight2294.71 Da

Isoelectric Point (pI)5.97

Net Charge (pH 7.0)-1.09

Net Charge (pH 7.4) -1.42

Charge Density (pH 7.0) -0.0543

GRAVY Index0.85

Hydrophobic Moment 0.21

Boman Index0.35

Instability Index66.75

Aliphatic Index 126.50

Aromaticity 0.1000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 823.47

LogP -5.07

H-bond Donors 31.0

H-bond Acceptors 33.0

Rotatable Bonds 69.0

Heavy Atoms 159.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0152413 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/