Peptide Database

Peptide NameSLAY-screened peptide P4907

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC105H146N26O34S

DescriptionStandard

        TKYSHCDPYDLHNLYSSFSA
    

Molecular Weight2348.50 Da

Isoelectric Point (pI)5.91

Net Charge (pH 7.0)-1.44

Net Charge (pH 7.4) -1.75

Charge Density (pH 7.0) -0.0720

GRAVY Index-0.78

Hydrophobic Moment 0.36

Boman Index-0.03

Instability Index52.44

Aliphatic Index 44.00

Aromaticity 0.2000

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 970.34

LogP -10.52

H-bond Donors 35.0

H-bond Acceptors 36.0

Rotatable Bonds 70.0

Heavy Atoms 166.0

Ring Count 7.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0355388 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/