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MYP_007329
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Basic Information
xStAx-VHLL
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Standard
25 amino acids
C141H223N47O31
Standard
Sequence
RRWPRSLLDSHVRRVWRAALAPYIP
Physicochemical Analysis
3072.58 Da
12.00
4.85
4.59
0.1939
-0.54
0.82
-0.24
107.15
97.60
0.1200
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1265.00
-8.49
48.0
37.0
92.0
219.0
9.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0389979 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Axin-derived
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Acetylation
Amidation
Stapled: Ⓧ(6) and Ⓧ (10) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer β-catenin degrader Wnt/β-catenin signaling inhibitor
β-catenin
β-catenin degradation / Wnt signaling assay
PaperLiao H, Li X, Zhao L, Wang Y, Wang X, Wu Y, Zhou X, Fu W, Liu L, Hu HG, Chen YG. A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer. Cell Discov. 2020 Jun 9;6:38. PMID32550000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32550000/
RECORD: Rec_0431611 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Axin-derived
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Acetylation
Amidation
Stapled: Ⓧ(6) and Ⓧ (10) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer β-catenin degradation Wnt/β-catenin signaling inhibition Targeted protein degradation (PROTAC)
β-catenin; HEK293T cells; HCT116 cells; SW480 cells; LoVo cells
β-catenin degradation immunoblot
PaperxStAx-VHLL peptide PROTAC study; PMID:32550000 PMID32550000
RECORD: Rec_0431612 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Axin-derived
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Acetylation
Amidation
Stapled: Ⓧ(6) and Ⓧ (10) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer β-catenin degradation Wnt/β-catenin signaling inhibition Targeted protein degradation (PROTAC)
Wnt/β-catenin signaling; HEK293T cells
Topflash luciferase assay
PaperxStAx-VHLL peptide PROTAC study; PMID:32550000 PMID32550000