Peptide Database

Peptide NameNeurosecretory protein VGF fragment 8

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC87H135N25O24

DescriptionStandard

        NAPPEPVPPPRAAPAPTHV
    

Molecular Weight1915.16 Da

Isoelectric Point (pI)6.75

Net Charge (pH 7.0)-0.15

Net Charge (pH 7.4) -0.40

Charge Density (pH 7.0) -0.0079

GRAVY Index-0.66

Hydrophobic Moment 0.33

Boman Index0.06

Instability Index116.02

Aliphatic Index 51.58

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 708.00

LogP -7.08

H-bond Donors 19.0

H-bond Acceptors 25.0

Rotatable Bonds 43.0

Heavy Atoms 136.0

Ring Count 9.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0431571 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyNeuroendocrine regulatory peptide

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Insulin secretion β-cell function β-cell maintenance

TargetMIN6-K8 β cells; isolated human and mouse pancreatic islets

Methodglucose-stimulated insulin secretion (GSIS) assay

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