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MYP_007137
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Basic Information
Brevinin-2SSb
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
40 amino acids
C199H319N53O56S2
Standard
Sequence
SLFSLIKAGAKFLGKNMLKQGPQYPACKVSKDSENVNWKS
Physicochemical Analysis
4414.11 Da
9.81
4.45
4.21
0.1112
-0.47
0.60
-0.03
33.90
70.75
0.1000
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1790.00
-17.98
61.0
63.0
151.0
310.0
7.0
44.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0225542 VERIFIED: YES
Provenance & Taxonomy
Glandirana susurra [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli JCM 5491
128 μg/mL
MIC
PMID32751229 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32751229/
RECORD: Rec_0225570 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0249390 VERIFIED: YES
Provenance & Taxonomy
Glandirana susurra [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus JCM 2874
PMID32751229 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32751229/
RECORD: Rec_0274213 VERIFIED: YES
Provenance & Taxonomy
Glandirana susurra [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antioxidant
Escherichia coli, Salmonella enterica, and Pseudomonas aeruginosa and the fungus Candida albicans
30 μM
MIC
PaperAntimicrobial Property and Mode of Action of the Skin Peptides of the Sado Wrinkled Frog, Glandirana susurra, against Animal and Plant Pathogens.
RECORD: Rec_0282565 VERIFIED: YES
Provenance & Taxonomy
Glandirana susurra [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 32751229 PMID32751229 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32751229/
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