Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length32 amino acids

Chemical FormulaC160H268N40O54S

DescriptionStandard

        MEKETTIIESIQEVSLEELDQIIGAGKNFRLL
    

Molecular Weight3648.14 Da

Isoelectric Point (pI)4.31

Net Charge (pH 7.0)-4.48

Net Charge (pH 7.4) -4.71

Charge Density (pH 7.0) -0.1401

GRAVY Index-0.08

Hydrophobic Moment 0.53

Boman Index0.06

Instability Index35.64

Aliphatic Index 121.88

Aromaticity 0.0312

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1550.65

LogP -12.89

H-bond Donors 52.0

H-bond Acceptors 51.0

Rotatable Bonds 131.0

Heavy Atoms 255.0

Ring Count 1.0

Amide Bonds 34.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0309337 VERIFIED: NO

Provenance & Taxonomy

OrganismStreptococcus dysgalactiae subsp. dysgalactiae [Bacterium]

FamilyLantibiotic

Tax ID663952

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence