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MYP_007051
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Basic Information
Esculentin-2P (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Antiviral ▸ Virucidal activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
37 amino acids
C173H290N50O46S2
Standard
Sequence
GFSSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC
Physicochemical Analysis
3870.59 Da
10.21
5.74
5.50
0.1550
0.36
0.75
0.09
21.98
97.57
0.0811
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1569.22
-16.32
58.0
54.0
135.0
271.0
3.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0200617 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antiviral
Channel Catfish Virus: 90% inhibition at 50 μM
PMID11601906;10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/
RECORD: Rec_0226709 VERIFIED: YES
Provenance & Taxonomy
Anura [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Virucidal
Frog virus 3 (Virucidal); FHM
80 %
Plaque assay
PaperInactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin. | Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L. | Virology. 2001 | PMID:11601906 PMID11601906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/
RECORD: Rec_0236504 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antiviral
PMID11601906;10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/
RECORD: Rec_0295076 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antiviral
Escherichia coli
10 μM
MIC
PMID11601906;10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/
RECORD: Rec_0304499 VERIFIED: YES
Provenance & Taxonomy
Anura [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Virucidal
Channel catfish virus (Virucidal); CCO
90 %
Plaque assay
PaperInactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin. | Chinchar VG, Wang J, Murti G, Carey C, Rollins-Smith L. | Virology. 2001 | PMID:11601906 PMID11601906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/
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