‹ ›
MYP_007051
← PREVIOUS NEXT → BACK
Basic Information
Esculentin-2P (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Antiviral ▸ Virucidal activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
37 amino acids
C173H290N50O46S2
Standard
Sequence
GFSSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC
Physicochemical Analysis
3870.59 Da
10.21
5.74
5.50
0.1550
0.36
0.75
0.09
21.98
97.57
0.0811
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1569.22
-16.32
58.0
54.0
135.0
271.0
3.0
38.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0016209 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antiviral
Virus
PMID11601906;10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/
RECORD: Rec_0023505 VERIFIED: YES
Provenance & Taxonomy
Rana pipiens [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antiviral
Frog Virus 3: 90% inhibition at 500 μM
PMID11601906;10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11601906/
RECORD: Rec_0027229 VERIFIED: NO
Provenance & Taxonomy
Rana pipiens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPatent US 7862826 B2 Evidence URLhttps://patents.google.com/patent/US7862826B2/en PatentUS 7862826 B2
RECORD: Rec_0051025 VERIFIED: YES
Provenance & Taxonomy
American frog [Animal]
Esculentin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
31-37
Bio-Activity Profile
Antimicrobial
PMID10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/
RECORD: Rec_0106812 VERIFIED: YES
Provenance & Taxonomy
Lithobates pipiens [Animal]
8404
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
T cells
30 %
Inhibition
PaperAntimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells. PMID16140737 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16140737/
1 2 3 4 NEXT LAST
Showing 5 records on this page · Page 1 of 4