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MYP_006916
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Basic Information
A12L/A20L/A23L
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
26 amino acids
C148H248N36O34
Standard
Sequence
KWKSFLKTFKSLKKTVLHTLLKLISS
Physicochemical Analysis
3075.77 Da
10.78
6.84
6.58
0.2631
0.02
0.69
0.01
0.03
116.15
0.1154
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1159.04
-6.31
43.0
42.0
109.0
218.0
5.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0326910 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
PeptideV13K
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
A-549
9.2 μM
IC50
PaperStudies on mechanism of action of anticancer peptides by modulation of hydrophobicity within a defined structural framework PMID21252288 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21252288/
RECORD: Rec_0331794 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
PeptideV13K
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
RD
5.5 μM
IC50
PaperStudies on mechanism of action of anticancer peptides by modulation of hydrophobicity within a defined structural framework PMID21252288 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21252288/
RECORD: Rec_0366371 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic designed peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antimycobacterial
Mycobacterium tuberculosis H37Rv multidrug resistant strain vertulo
MIC
PMID20858205 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20858205/
RECORD: Rec_0383124 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0391793 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
3.5 μg/mL
HC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/20858205/ PMID20858205 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20858205/
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