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MYP_006833
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Basic Information
Ac-H2-(7-15)
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Standard
9 amino acids
C41H64N10O14
Standard
Sequence
YAGAVVNDL
Physicochemical Analysis
921.01 Da
4.05
-1.24
-1.44
-0.1378
0.79
0.37
0.39
25.77
130.00
0.1111
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
396.74
-3.40
13.0
13.0
27.0
65.0
1.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0062446 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Herpes simplex virus type 1:inhibition of HSV-1 ribonucleotide reductase activity
76 μM
IC50
PaperPubMed PMID: 3040743 PMID3040743 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3040743/
RECORD: Rec_0072096 VERIFIED: YES
Provenance & Taxonomy
Human alphaherpesvirus 1 [Virus]
Virus-derived peptide
10298;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Herpes simplex virus 1 (Replication); BHK-21/C13
52 μM
Ribonucleotide reductase assay
PaperMechanism of inhibition of herpes simplex virus (HSV) ribonucleotide reductase by a nonapeptide corresponding to the carboxyl terminus of its subunit 2. Specific binding of a photoaffinity analog, [4'- azido-Phe6] HSV H2-6(6-15), to subunit 1. | Paradis H, Gaudreau P, Brazeau P, Langelier Y. | J Biol Chem. 1988 | PMID:2846533 PMID2846533 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2846533/
RECORD: Rec_0077310 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Herpes simplex virus type 1:inhibition of HSV-1 ribonucleotide reductase activity
190 μM
IC50
PaperPubMed PMID: 3040743 PMID3040743 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3040743/
RECORD: Rec_0114820 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide (D-Ala2) [Mixed]
Acetylation
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 3040743 PMID3040743 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3040743/
RECORD: Rec_0116609 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 55.6%, C 44.4% [Linear]
canonical L-amino-acid peptide [L]
Acetylation
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
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