Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length474 amino acids

Chemical FormulaC2340H3734N588O674S20

DescriptionStandard

        KMSPCCWLALLALVPFALATNPGVKVKLTEKGIEYGKQIGMASLQQKLKTMKVPDLSGTERVAPIGKVKYSLTGITIVNLGLPYSALALVPDTGISLSITNAFISLHGNWKIRYLSFIKDSGSFDLEVNGLTVTDSITIKSDETGRPTVSSVNCVANVGSASIKFHGGASWLYNLFSAYIDKALRSALQKQICPLVADTITDMNPHLKTLNVLAKVDKYAEVEYSMVTSPTISNASIDFSLKGEFYNIGKHQEPPFSPTPFSLPPQVNNMLYIGMSAFTTNSAGFVYNNAGALSLYITDDMIPPSSPIRLNTRTFGAFIPEIAKRFPSMMMKLLVKTVKEPTIFFEPNNVTVQASGSVTAYAIQPNTTLSPLFVLNMEGSVSARLYVTGVKLAGAVTLNKIEMTLETSYVGQFQVRSLDNIFLMVLKVAVIPKVNARLEKGFPLPSIGKMNLVNTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight51529.51 Da

Isoelectric Point (pI)9.20

Net Charge (pH 7.0)10.08

Net Charge (pH 7.4) 9.51

Charge Density (pH 7.0) 0.0213

GRAVY Index0.19

Hydrophobic Moment 0.70

Boman Index0.17

Instability Index30.51

Aliphatic Index 99.73

Aromaticity 0.0865

Extinction Coeff. Reduced 40340.00

Extinction Coeff. Oxidized 40590.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0105577 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus mykiss [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence