‹ ›
MYP_006676
← PREVIOUS NEXT → BACK
Basic Information
Antifungal peptide 2 (EAFP2; Plant defensin)
Antimicrobial
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
41 amino acids
C163H259N57O53S10
Standard
Sequence
QTCASRCPRPCNAGLCCSIYGYCGSGAAYCGAGNCRCQCRG
Physicochemical Analysis
4185.80 Da
8.62
3.66
3.30
0.0892
-0.07
0.53
-0.03
3.37
31.22
0.0732
4470.00
5095.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1771.31
-28.75
73.0
67.0
129.0
283.0
5.0
44.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0170630 VERIFIED: YES
Provenance & Taxonomy
Eucommia ulmoides [Plant]
Hevein, Chitin-binding
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Pyroglutamate
disulfide bond reported, sites not specified
N-terminal pyroglutamate
Bio-Activity Profile
Antimicrobial Antifungal
Ascochyta lycopersici
109 μg/mL
IC50
PaperPubMed PMID 12067732 | PubMed PMID 15147180 PMID12067732;15147180 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12067732/
RECORD: Rec_0173495 VERIFIED: YES
Provenance & Taxonomy
Eucommia ulmoides [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
3-17; 7-37; 11-23; 16-30; 35-39
Bio-Activity Profile
Antimicrobial Antifungal Host defense
PaperPDB 1P9Z structural record; NMR; chain A; residues 2-41
RECORD: Rec_0208690 VERIFIED: YES
Provenance & Taxonomy
Eucommia ulmoides [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Defense peptide Non-hemolytic
A. lycopersici
PMID12067732;15147184;15363789 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12067732/
RECORD: Rec_0240480 VERIFIED: YES
Provenance & Taxonomy
Eucommia ulmoides [Plant]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
N-terminus is blocked by pyroglutamate. This is the first finding of a plant antifungal peptide with a five-disulfide motif. The five S-S bonds are C1-C5, C2-C9, C3-C6, C4-C7, and C8-C10. EAFP1 and EAFP2 show characteristics of hevein domain and exhibit chitin-binding properties similar to the previously identified hevein-like peptides. They exhibit relatively broad spectra of antifungal activities against eight pathogenic fungi from cotton, wheat, potato, tomato and tobacco. You can rotate, zoom, and view the 3D structure here in the PDB . Updated 2/2014
Bio-Activity Profile
Antifungal
PaperTwo novel antifungal peptides distinct with a five-disulfide motif from the bark of Eucommia ulmoides Oliv.
RECORD: Rec_0243465 VERIFIED: YES
Provenance & Taxonomy
Eucommia ulmoides [Plant]
Hevein, Chitin-binding
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Pyroglutamate
disulfide bond reported, sites not specified
N-terminal pyroglutamate
Bio-Activity Profile
Antimicrobial Antifungal
Alternaria nicotianae
PaperPubMed PMID 12067732 | PubMed PMID 15147180 PMID12067732;15147180 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12067732/
FIRST PREV 1 2 3 4 5 6 NEXT LAST
Showing 5 records on this page · Page 3 of 6