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MYP_006668
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Basic Information
SPMI-HIF2-1
Anticancer
Standard
18 amino acids
C97H140N22O26
Standard
Sequence
TSFREYWALLSALAAYAP
Physicochemical Analysis
2030.28 Da
5.66
-0.60
-0.80
-0.0334
0.43
0.44
0.29
19.19
92.78
0.2222
8480.00
8480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
765.37
-4.26
28.0
26.0
58.0
145.0
6.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0071218 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
MDM2/MDMX-binding peptide
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(4) and Ⓧ (11) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
HCT116 p53+/+
10.8 μM
IC50
PaperChen S, Li X, Li Y, Yuan X, Geng C, Gao S, Li J, Ma B, Wang Z, Lu W, Hu HG. Design of stapled peptide-based PROTACs for MDM2/MDMX atypical degradation and tumor suppression. Theranostics. 2022 Sep 11;12(15):6665-6687. PMID36185610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36185610/
RECORD: Rec_0120100 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
MDM2/MDMX-binding peptide
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(4) and Ⓧ (11) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
HCT116 p53-/-
>100 μM
IC50
PaperChen S, Li X, Li Y, Yuan X, Geng C, Gao S, Li J, Ma B, Wang Z, Lu W, Hu HG. Design of stapled peptide-based PROTACs for MDM2/MDMX atypical degradation and tumor suppression. Theranostics. 2022 Sep 11;12(15):6665-6689. PMID36185610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36185610/
RECORD: Rec_0305248 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
MDM2/MDMX-binding peptide
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(4) and Ⓧ (11) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
HCT116 p53+/+
15.2 μM
IC50
PaperChen S, Li X, Li Y, Yuan X, Geng C, Gao S, Li J, Ma B, Wang Z, Lu W, Hu HG. Design of stapled peptide-based PROTACs for MDM2/MDMX atypical degradation and tumor suppression. Theranostics. 2022 Sep 11;12(15):6665-6688. PMID36185610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36185610/
RECORD: Rec_0397414 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
MDM2/MDMX-binding peptide
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(4) and Ⓧ (11) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
HCT116 p53+/+
6.7 μM
IC50
PaperChen S, Li X, Li Y, Yuan X, Geng C, Gao S, Li J, Ma B, Wang Z, Lu W, Hu HG. Design of stapled peptide-based PROTACs for MDM2/MDMX atypical degradation and tumor suppression. Theranostics. 2022 Sep 11;12(15):6665-6689. PMID36185610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36185610/