Peptide Database

Peptide NamesHR1

Function Ontology

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Standard StatusStandard

Sequence Length96 amino acids

Chemical FormulaC465H766N132O152

DescriptionStandard

        AYRFNGIQVTQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLIT
    

Molecular Weight10637.85 Da

Isoelectric Point (pI)6.40

Net Charge (pH 7.0)-0.20

Net Charge (pH 7.4) -0.40

Charge Density (pH 7.0) -0.0020

GRAVY Index-0.20

Hydrophobic Moment 0.71

Boman Index0.00

Instability Index18.18

Aliphatic Index 109.69

Aromaticity 0.0521

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4733.91

LogP -56.41

H-bond Donors 158.0

H-bond Acceptors 152.0

Rotatable Bonds 370.0

Heavy Atoms 749.0

Ring Count 5.0

Amide Bonds 117.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0116993 VERIFIED: YES

Provenance & Taxonomy

OrganismSevere acute respiratory syndrome-related coronavirus [Virus]

FamilyVirus-derived peptide

Tax ID694009;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor

TargetSARS coronavirus (Fusion); Vero

Activity50 μM

MethodEC50

PaperSevere acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides. | Bosch BJ, Martina BE, Van Der Zee R, Lepault J, Haijema BJ, Versluis C, Heck AJ, De Groot R, Osterhaus AD, Rottier PJ. | Proc Natl Acad Sci U S A. 2004 | PMID:15150417 PMID15150417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15150417/

RECORD: Rec_0368238 VERIFIED: YES