Peptide Database

Peptide Namepep1c

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Standard StatusStandard

Sequence Length9 amino acids

Chemical FormulaC46H65N13O19

DescriptionStandard

        DKFNHEAED
    

Molecular Weight1104.08 Da

Isoelectric Point (pI)4.49

Net Charge (pH 7.0)-3.14

Net Charge (pH 7.4) -3.40

Charge Density (pH 7.0) -0.3492

GRAVY Index-2.22

Hydrophobic Moment 0.48

Boman Index-0.46

Instability Index20.86

Aliphatic Index 11.11

Aromaticity 0.1111

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 543.11

LogP -5.81

H-bond Donors 17.0

H-bond Acceptors 17.0

Rotatable Bonds 37.0

Heavy Atoms 78.0

Ring Count 2.0

Amide Bonds 9.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0295963 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV Entry inhibition

TargetSARS-CoV | HeLa cells

Activity100 μM

Method% inhibition

Half-LifeMammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h

PaperIdentification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor. | Han DP, Penn-Nicholson A, Cho MW. | Virology. 2006 Jun 20;350(1):15-25. | DOI:10.1016/j.virol.2006.01.029 | PMID:16510163 PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/

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